王俊岩

学位： 博士

职称： 副研究员

教育工作经历：

2021/7至今 永利集团3044官网欢迎您 方剂学教研室 教师

2021/7至今 永利集团3044官网欢迎您 中西医结合流动站 博士后  

2018/09-2021/06 永利集团3044官网欢迎您 中医内科学 博士

2015/09-2018/06 辽宁中医药大学 中西医结合临床 硕士

2010/09-2015/07 辽宁中医药大学 中西医临床医学 学士

研究方向

中医药防治心血管疾病基础与临床研究

科研及教学课题：

1. 国家自然科学基金-面上项目，No.82474401，基于NR6A1/NR3C2通路介导的醛固酮逃逸探讨益气温阳活血利水法防治心力衰竭的作用机制，51万元，2025.1-2028.12主持，在研

2. 国家自然科学基金，青年基金，No. 82204990，基于MLK3/RIPK3/FUNDC1通路介导的线粒体未折叠蛋白反应-铁死亡探讨益气温阳活血利水法防治心力衰竭的机制，30万元，2023.1-2025.12，主持，在研

3. 广州市科技局计划项目，益气温阳活血利水法调控醛固酮突破防治慢性心力衰竭作用机制研究，5万元，2025.1-2026.12，主持，在研

4. 中医证候全国重点实验室开放课题重点项目，基于巨噬细胞ZBTB18介导的能量代谢时空重构探讨芪参颗粒防治心力衰竭气虚血瘀证的作用机制，30万元，主持，在研

5. 中医湿证国家重点实验室开放课题，基于 Nr2f1/CaMKII信号介导的线粒体功能紊乱-醛固酮逃逸探讨慢性心力衰竭阳虚水泛(湿)证生物学基础及真武汤的干预作用，10万元，2024.1-2025.12主持，在研

6. 中国博士后科学基金，第15批特别资助（站中），No.2022T150149，益气温阳活血利水法调控线粒体质量控制防治心力衰竭作用机制研究，18万元，2022.07-2023.06，主持，结题

7. 中国博士后科学基金，第70批面上资助，No.2021M700966，基于MLK3/PINK1/Parkin介导的线粒体自噬-铁死亡探讨益气温阳活血利水法防治慢性心力衰竭的作用及机制，8万元, 2021.11-2023.06，主持，结题

承担课程：

主要承担《方剂学》等课程。

代表性研究论文

1. Junyan Wang^#, Xiangyi Pu^#, Haowen Zhuang^#, ZhijiangGuo, Mengyuan Wang,Huaihong Yang*, Chun Li*, Xing Chang*.Astragaloside IV alleviates septic myocardial injury through DUSP1-Prohibitin 2 mediated mitochondrial quality control and ER-autophagy. Journal of Advanced Research, 2024.

2. Haowen Zhuang^#, Chun Li^#, Lingjun Wang^#, Bei Zhou, Zhijiang Guo, Yusheng Huang, Bo Deng, Yulin Ouyang1, Junxiong Qiu, Xing Chang*, Wei Wang*, Junyan Wang*. High-Throughput Screening of an FDA-Approved Compound Library Reveals a Novel GAS6 Receptor Agonist for Therapeutic Intervention in Septic Myocardial and microvascular Injury via Modulation of Danger-Associated Molecular Patterns. International Journal of Biological Sciences, 2024,20(15):6222-6240.

3.Wang Junyan, Deng Bo, Liu Qing, Huang Yusheng, Chen Weitao, Li Jing, Zhou Zheng, Zhang Lu, Liang Birong, He Jiaqi, Chen Zixin, Yan Cui, Yang Zhongqi, Xian Shaoxiang*, Wang Lingjun*. Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload. Cell Death & Disease, 2020, 11(07): 574

4. Xin Dong^#, HaoWen Zhuang^#, RuiJia Wen^#, YuSheng Huang, BingXue Liang, Huan Li, ShaoXiang Xian, Chun Li*, LingJun Wang*, JunYan Wang*. Xinyang tablet alleviated cardiac dysfunction in a cardiac pressure overload model by regulating the receptor-interacting serum/ three- protein kinase 3/FUN14 domain containing 1-mediated mitochondrial unfolded protein response and mitophagy. Journal of Ethnopharmacology, 2024,330:118152.

5. Junyan Wang^#, Haowen Zhuang^#, Lianqun Jia^#, Xinyong He, Sicheng Zheng, Kangshou Ji, Kang Xie, Tong Ying, Ying Zhang*, Chun Li*, Xing Chang*.Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy. International Journal of Biological Sciences, 2024,20(11):4458-4475.

6. Junyan Wang^#, Haowen Zhuang^#, Xiaocui Yang^#, Zhijiang Guo, Kainan Zhou, Nanyang Liu, Yang An, Ye Chen, Zhongzheng Zhang, Mengyuan Wang, Jinhong Chen, Chun Li*, Xing Chang*. Exploring the Mechanism of Ferroptosis Induction by Sappanone A in Cancer: Insights into the Mitochondrial Dysfunction Mediated by NRF2/xCT/GPX4 Axis. International Journal of Biological Sciences, 2024,20(13):5145-5161.

7. Fengxiang Pang^#, Shouchang Ding^#, Nan Li, Zhipeng Li, Nannan Tian, Chuanjian Shi, Fengwei Zhang, Yongxin Mai, Jinfang Zhang*, Junyan Wang*. Gallic acid mediates tumor-suppressive effects on osteosarcoma through the H19-Wnt/β-catenin regulatory axis. Journal of Orthopaedic Translation,2023(39):34–42.

8. Junyan Wang^#, Bo Deng^#, Jing Liu, Qing Liu, Yining Guo, Zhongqi Yang, Chongkai Fang, Lu Lu, Zixin Chen, Shaoxiang Xian*, Lingjun Wang*, Yusheng Huang*.Xinyang Tablet inhibits MLK3-mediated pyroptosis to attenuate inflammation and cardiac dysfunction in pressure overload. Journal of Ethnopharmacology, 2021,274:114078.

9. RuiJia Wen, Xin Don, HaoWen Zhuang, FengXiang Pang, ShouChang Ding, Nan Li, YongXin Mai, ShuTing Zhou, JunYan Wang*, JinFang Zhang*.Baicalin induces ferroptosis in osteosarcomas through a novel Nrf2/xCT/ GPX4 regulatory axis. Phytomedicine, 2023,116:154881.

10. Xin Dong, Ruijia Wen, Yuanyuan Xiong, Xiaotong Jia, Xiwen Zhang, Xin Li, Liangyou Zhang, Zhibin Li, Shu Zhang, Yanna Yu, Qiang Li, Xingbo Wu, Haitao Tu, Zixin Chen, Shaoxiang Xian, Lingjun Wang, Chao Wang*, Lianqun Jia*, Junyan Wang*, Gangyi Chen*.Emodin alleviates CRS4-induced mitochondrial damage via activation of the PGC1α signaling. Phytotherapy Research,2024 38(3):1345-1357.