国际中医药转化医学研究所
王彩艳
发布时间:2019-06-06      来源:       点击:

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职称:教授 学位:博士

导师类型:硕/博士生导师

学院: 永利集团3044官网欢迎您

E-mail: wangcaiyan@gzucm.edu.cn

办公电话:020-39358875

办公室:广州大学城永利集团3044官网欢迎您针灸楼2楼

个人获得荣誉:国家优青获得者、广东省青年珠江学者、中药学交叉创新学科带头人、“杏林青年学者”

教育工作经历:

2015年博士毕业于中山大学,随后在中山大学“有害生物控制与资源利用国家重点实验室”从事博士后研究。

2019年美国加州大学洛杉矶分校分子成像中心访问学者。2017年以“杏林青年学者”身份引进到永利集团3044官网欢迎您工作至今。

现为中医证候全国重点实验室固定成员、中医药广东省实验室兼职成员。

研究方向:

研究领域:中药抗炎结构药理学

研究方向:(1)中药药效分子作用靶点发现与确证;

(2)基于“成分-靶点”互作结构的抗炎机制解析。

科研课题:

1. 中医药广东省实验室(横琴实验室), HQL2024PZ038, 2024.08-2026.08, 120万元,主持,在研。

2. 中医证候全国重点实验室, SKLKY2024A0006, 2024.08-2026.08, 20万元, 指导教师,在研。

3. 中医证候全国重点实验室, SKLKY2024A0007, 2024.08-2026.08, 20万元, 指导教师,在研。

4. 国家自然科学基金优秀青年科学基金项目,82322074, 2024/01-2026/12,200万元,主持,在研。

5. 永利集团3044官网欢迎您青年拔尖人才 (团队) 培育“揭榜挂帅”项目,2023/09-2026/09,50万元,主持,在研。

6. 国家自然科学基金面上项目,82274214,2023/01-2026/12,52万元,主持,在研。

7. 广东省教育厅重点领域项目,2022ZDZX2010,2023/01-2025/12,10万元,主持,在研。

8. 广州市基础与应用基础研究项目,202201011420,2022/04-2024/03,5万元,主持,在研。

9. 广东省教育厅,2019年广东省高等学校青年珠江学者,2019/10-2022/09, 100万,主持,结题。

10. 国家自然科学基金青年项目,31700625,2018/01-2020/12,24万元,主持,结题。

11. 广东省基础与应用基础面上项目,2017A030310190,2017/05-2020/5,10万元,主持,结题。

12. 中国博士后科学基金特别资助,2017T100654,2017/01-2017/06,15万元,主持,结题。

承担课程:

本科生教学:《药理学》《药物毒理学》和《结构生物学与现代药学研究》;

研究生教学:《药学专论》蛋白质结构药理学部分。

代表性论文:

1. Zuhui Liang#, Yingyi Ye#, Zhihong Deng#, Huan Lan, Caihong Liu, Yuanhang Xu, Minqi Fan, Zhongqiu Liu, Peng Wu*, Lin An*, Caiyan Wang *(王彩艳,最后通讯). CHPF2 as a novel biomarker and ponicidin as a potential therapeutic agent in hepatocellular carcinoma. Pharmacological Research, 2025, Accepted.

2. Minqi Fan, Yuanhang Xu, Bingxin Wu, Jiachan Long, Caihong Liu, Zuhui Liang, Rong Zhang, Zhongqiu Liu*, Caiyan Wang*(王彩艳,最后通讯). Geniposidic Acid Targeting FXR "S332 and H447" Mediated Conformational Change to Upregulate CYPs and miR-19a-3p to Ameliorate Drug-Induced Liver Injury. Advanced Science, 2025, doi:10.1002/advs.202409107.

3. Ying Zhang#, Huan Lan#, Wenjuan Zhai, Lin Jiang, Xiaotong Xia, Fang liu, Lin Zhang, Jinjun Wu*, Zhongqiu Liu*, Caiyan Wang*(王彩艳,最后通讯). Caffeic acid alleviates myocardialischemia-reperfusion injury by directlytargeting Keap1N532/M550 and promotingits degradation. Journal of Pharmaceutical Analysis, 2025, doi.org/10.1016/j.jpha.2025.101219.

4. Bixin Zhao#, Zuhui Liang#, Lisheng Zhang#, Lin Jiang, Yuanhang Xu, Ying Zhang, Rong Zhang*, Caiyan Wang*(王彩艳,共同通讯). Zhongqiu Liu*, Ponicidin promotes hepatocellular carcinoma mitochondrial apoptosis by stabilizing Keap1-PGAM5 complex. Advanced Science, 2024, doi:10.1002/advs.202406080.

5. Ying Zhang#, Wenjuan Zhai#, Minqi Fan#, Jinjun Wu*, Caiyan Wang* (王彩艳,最后通讯). Salvianolic Acid B Significantly Suppresses the Migration of Melanoma Cells via Direct Interaction with β-Actin. Molecules, 2024, doi:10.3390/molecules29040906.

6. Xiaojun Teng#, Bingxin Wu#, Zuhui Liang, Lisheng Zhang, Maolin Yang Zhongqiu Liu*,·Qi Liang*, Caiyan Wang*(王彩艳,最后通讯). Three bioactive compounds from Huangqin decoction ameliorate Irinotecan-induced diarrhea via dual-targeting of Escherichia coli and bacterial β-glucuronidase, Cell Biol Toxicol., 2024;40(1):88. doi: 10.1007/s10565-024-09922-0.

7. Bingxin Wu, Zuhui Liang, Huan Lan, Xiaojun Teng, Caiyan Wang* (王彩艳,唯一通讯). The role of PKM2 in cancer progression and its structural and biological basis, Journal of Physiology and Biochemistry, 2024; 80(2):261-275. doi:10.1007/s13105-024-01007-0

8. Jiachan Long, Yuanhang Xu, Xuerong Zhang, Bingxing Wu, Caiyan Wang* (王彩艳,唯一通讯). Role of FXR in the development of NAFLD and intervention strategies of small. Archives of Biochemistry and Biophysics, 2024;757:110024. doi:10.1016/j.abb.2024.110024.

9. Xuerong Zhang, Yuanhang Xu, Minqi Fan, Xueqing Lv, Jiachan LongaRong Yang, Rong Zhang, Zhongqiu Liu, Jiangyong Gu*, Peng Wu* CaiyanWang*(王彩艳,最后通讯). Ponicidin-induced conformational changes of HSP90 regulates the MAPK pathway to relieve ulcerative colitis. Journal of Ethnopharmacology, 2024;321:117483. doi:10.1016/j.jep.2023.117483

10. Caiyan Wang#(王彩艳,第一作者), Xiaojun Teng#, Chuang Wang#, Binjie Liu, Runze Zhou, Xueyu Xu, Huawei Qiu, Yu Fu, Rongjin Sun, Zuhui Liang, Rong Zhang, Zhongqiu Liu*, Lin Zhang*, Lijun Zhu*. Insight into the mechanism of Xiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea based on regulating the gut microbiota and inhibiting Gut β-GUS. Phytomedicine, 2023;120:155040. doi:10.1016/j.phymed.2023.155040

11. Huan Lan, Ying Zhang, Minqi Fan, Bingxin Wu, Caiyan Wang*(王彩艳,唯一通讯). Pregnane X receptor as a therapeutic target for cholestatic liver injury. Drug metabolism reviews, 2023; 55(4): 371-387. doi:10.1080/03602532.2023.2248680

12. Fang Wu#, Yuanyuan Cheng#, Jianfu Zhou#, Xuehua Liu, Rongwu Lin, Songtao Xiang, Zhongqiu Liu*, Caiyan Wang*(王彩艳,最后通讯). Zn2+ regulates human oxalate metabolism by manipulating oxalate decarboxylase to treat calcium oxalate stones. Int J Biol Macromol. 2023;234:123320. doi:10.1016/j.ijbiomac.2023.123320

13. Zibo Li#, Lin Jiang#, Jiadong Ni, Yuanhang Xu, Fang Liu, Wenming Liu, Shaogui Wang*, Zhongqiu Liu*, Caiyan Wang*(王彩艳,最后通讯). Salvianolic acid B Suppresses Hepatic Fibrosis by Targeting Ceramide Glucosyltransferase in Hepatic Stellate Cells. Acta Pharmacologica Sinica, 2023, 44(6):1191-1205.

14. Lin Zhang, Yuanhang Xu, Xuerong Zhang, Yibing Yang, Jiangyong Gu, Zhongqiu Liu*, Caiyan Wang*(王彩艳,最后通讯). The Structural Basis of Conserved Residue Variant Effect on Enzyme Activity of UGT2B15, BBA - Proteins and Proteomic, 2023;1871(3):140888. doi:10.1016/j.bbapap.2023.140888

15. TianTian Wang#, LiChun Zhang#, Zhen Qin, ShuJun Chen , JingMin Zeng, JingYan Li, Lin An, Caiyan Wang(王彩艳, 参与作者), Yong Gao, Liming Wang, Zhongxiang Zhao*, Zhongqiu Liu*, Shaogui Wang*. Decreased syntaxin17 expression contributes to the pathogenesis of acute pancreatitis in murine models by impairing autophagic degradation. Acta Pharmacol Sin. 2023, doi: 10.1038/s41401-023-01139-x.

16. Tao Su, Suchao Huang, Yanmin Zhang, Yajuan Guo, Shuwei Zhang, Jiaji Guan, Mingjing Meng, Linxin Liu, Caiyan Wang(王彩艳, 参与作者), Dihua Yu, Hiu-Yee Kwan, Zhiying Huang, Qiuju Huang, Elaine Lai-Han Leung, Ming Hu, Ying Wang, Zhongqiu Liu*, Linlin Lu*. miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis. Acta Pharm Sin B. 2022;12(2):821-837. doi:10.1016/j.apsb.2021.06.009.

17. Juan Liu, Yuxin Zhuang, Jianlin Wu, Qiang Wu, Meixian Liu, Yue Zhao, Zhongqiu Liu, Caiyan Wang(王彩艳, 参与作者), Linlin Lu, Yingjiao Meng, Kawai Lei, Xiaojuan Li, Qibiao Wu, Elaine Lai-Han Leung, Zhengyang Guo, Liang Liu*, Ting Li*. IKKβ mediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα. Acta Pharm Sin B. 2022;12(2):651-664. doi:10.1016/j.apsb.2021.09.012.

18. Baoyuan Huang, Qiumei Wang, Lin Jiang, Shuru Lu, Chengcheng Li, Chunqi Xu, Caiyan Wang*(王彩艳,共同通讯), Enxin Zhang*, Xiaojun Zhang*. Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages. Frontiers in Pharmacology, 2022 Aug 17. doi:10.3389/fphar.2022.926945.

19. Lin Zhang#, Wei Xie#, Xiaojun Teng, Kui Wang, Wei Xie*, Caiyan Wang*(王彩艳,最后通讯). Improving the Extraction of Active Ingredients from Medicinal Plants by XynA Modification. Journal of Chemistry, 2022, doi:10.1155/2022/2483797.

20. Xuerong Zhang#, Shehan Li#, Zibo Li, Liangkai Cheng, Zhongqiu Liu*, Caiyan Wang*(王彩艳,最后通讯). The Therapeutic Potential of Targeting Hsp90-Cdc37 Interactions in Several Diseases. Current Drug Targets, 2 2022;23(10):1023-1038. doi:10.2174/1389450123666220408101544.

21. Zibo Li, Lin Zhang, Dan Liu, Caiyan Wang*(王彩艳,唯一通讯). Ceramide glycosylation and related enzymes in cancer signaling and therapy. Biomedicine & Pharmacotherapy, 2021;139:111565. doi:10.1016/j.biopha.2021.111565.

22. Yuanyuan Cheng#, Liangkai Cheng#, Xiang Gao, Sixuan Chen, Peng Wu, Caiyan Wang*(王彩艳,共同通讯), Zhongqiu Liu*. Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury. Theranostics, 2021;11(2):861-877. doi:10.7150/thno.48436.

23. Dan Liu,Qi Yu,Zibo Li,Lin Zhang,Ming Hu,Caiyan Wang*(王彩艳,共同通讯),Zhongqiu Liu*, UGT1A1 dysfunction increases liver burden and aggravates hepatocyte damage caused by long-term bilirubin metabolism disorder. Biochemical Pharmacology, 2021;190:114592. doi:10.1016/j.bcp.2021.114592.

24. Ping He#, Chunnian Wang#, Yanlan Wang#, Caiyan Wang# (王彩艳,共同一作), Changhua Zhou, Donglin Cao, Jiang Li, David A. Bushnell, Qing Li, Roger D. Kornberg*, Wei Xie*, Zhong Wang*. A Novel AKR1C3 Specific Prodrug TH3424 With Potent Antitumor Activity in Liver Cancer. Clinical Pharmacology & Therapeutics, 2021; 110(1):229-237. doi: 10.1002/cpt.2171.

25. Liangkai Cheng, Huihui Wang, Shehan Li, Zhongqiu Liu, Caiyan Wang*(王彩艳,唯一通讯). New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutations. Life Sciences, 2021;282:119791. doi:10.1016/j.lfs.2021.119791.

26. Wei Xie, Qi Yu, Ruiqing Zhang, Yun Liu, Ruoting Cao, Sidi Wang, Ruoting Zhan, Zhongqiu Liu, Kui Wang*, Caiyan Wang*(王彩艳,最后通讯). Insights into the Catalytic Mechanism of a Novel XynA and Structure-Based Engineering for Improving Bifunctional Activities. Biochemistry, 2021;60(26):2071-2083. doi:10.1021/acs.biochem.1c00134 3.

27. Ying Zhang, Caiyan Wang*(王彩艳,唯一通讯). Demethyltransferase AlkBH1 Substrate Diversity and Relationship to Human Diseases. Molecular Biology Reports, 2021;48(5):4747-4756. doi:10.1007/s11033-021-06421-x.

28. Wei Liu#, Yanxiang Cui#, Caiyan Wang (王彩艳, 参与作者), Zihang Li, Danyang Gong, Xinghong Dai, Guo-Qiang Bi, Ren Sun, Z Hong Zhou*. Structures of capsid and capsid-associated tegument complex inside the Epstein-Barr virus. Nature Microbiology, 2020;5(10):1285-1298. doi:10.1038/s41564-020-0758-1.

29. Liangkai Cheng#, Hong Zhang#, Fang Wu, Zhongqiu Liu, Yuanyuan Cheng*, Caiyan Wang*(王彩艳,最后通讯). Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease. Oxidative Medicine and Cellular Longevity, 2020, doi:10.1155/2020/4683943.

30. Lin Zhang#, Lijun Zhu#, Wei Qu, Fang Wu, Ming Hu, Wei Xei*, Zhongqiu Liu*, Caiyan Wang*(王彩艳,最后通讯). Insight into tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15. Biochemical Pharmacology, 2020;172:113753. doi:10.1016/j.bcp.2019.113753.

31. Hong Li#, Ying Zhang#, Yajuan Guo, Rong Liu, Qi Yu, Lingzhi Gong, Zhongqiu Liu*, Wei Xie*, Caiyan Wang*(王彩艳,最后通讯). ALKBH1 Promotes Lung Cancer by Regulating m6A RNA Demethylation. Biochemical Pharmacology, 2021;189:114284. doi:10.1016/j.bcp.2020.114284.

32. Qi Yu, Zonglang Liao, Dan Liu, Wei Xie, Zhongqiu Liu, Guochao Liao*, Caiyan Wang*(王彩艳,最后通讯). Small molecule inhibitors of the prostate cancer target KMT2D. Biochemical and Biophysical Research Communications, 2020;533(3):540-547. doi:10.1016/j.bbrc.2020.09.004.

33. Dan Liu, Lin Zhang, Lixin Duan, Jinjun Wu, Ming Hu, Zhongqiu Liu*, Caiyan Wang*(王彩艳,最后通讯). Potential of Herb-Drug/Herb Interactions between Substrates and Inhibitors of UGTs Derived from Herbal Medicines. Pharmacological Research, 2019;150:104510. doi:10.1016/j.phrs.2019.104510.

34. Fang Wu, Liangkai Cheng, Qi Yu, Lin Zhang, Hong Li, Caiyan Wang*(王彩艳,唯一通讯). Purification and functional characterization of the C-terminal domain of the β-actin-binding protein AIM1 in vitro. Molecules, 2018, doi:10.3390/molecules23123281.

35. Caiyan Wang#(王彩艳,第一作者), Qian Jia#, Jianhua Zeng, Ran Chen, Wei Xie*. Structural insight into the methyltransfer mechanism of the bifunctional Trm5. Science Advances, 2017, doi:10.1126/sciadv.1700195.

36. Caiyan Wang(王彩艳,第一作者), Jianhua Zeng, Wei Xie*, A flexible cofactor-binding loop in the novel arginine methyltransferase Sfm1. FEBS Letters, 2017;591(2):433-441. doi:10.1002/1873-3468.12533.

37. Caiyan Wang#(王彩艳,第一作者), Qian Jia #, Ran Chen, Yuming Wei, Juntao Li, Jie Ma, Wei Xie*. Crystal structures of the bifunctional tRNA methyltransferase Trm5a. Scientific Reports, 2016. doi:10.1038/srep33553.

38. Caiyan Wang(王彩艳,第一作者), Yu Guo, Qingnan Tian, Qian Jia, Yuanzhu Gao, Qinfen Zhang, Chun Zhou, Wei Xie*. SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis. Nucleic Acids Research, 2015;43(21):10534-10545. doi:10.1093/nar/gkv996.

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